Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis
نویسندگان
چکیده
منابع مشابه
Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis
Protein degradation plays important roles in biological processes and is tightly regulated. Further, targeted proteolysis is an emerging research tool and therapeutic strategy. However, proteome-wide technologies to investigate the causes and consequences of protein degradation in biological systems are lacking. We developed "multiplexed proteome dynamics profiling" (mPDP), a mass-spectrometry-...
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ژورنال
عنوان ژورنال: Cell
سال: 2018
ISSN: 0092-8674
DOI: 10.1016/j.cell.2018.02.030